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Melasma is a very common skin disorder noticed in men and particularly women. It is quite commonly noticed in women that are pregnant and is also sometimes called the “mask of pregnancy”. Though it may affect anyone, women with brownish skin tones have reached greatest risk. Melasma is usually associated with the female hormones estrogen and progesterone. It is especially common in expectant women, girls that are taking birth control pills (oral contraceptives) and females taking hormone replacement therapy (HRT) during menopause. It can be prevalent in men and ladies of Native American descent (for the forearms) and that face men and some women of German/Russian and Jewish descent (around the face). The signs and symptoms of melasma are dark, irregular well demarcated hyperpigmented macules to patches commonly found around the upper cheek, nose, lips, upper lip, and forehead. These patches often develop gradually as time passes. Melasma will not cause every other symptoms at night cosmetic discoloration. An estimated six million women are living inside the U.S. with melasma and 45-50 million women worldwide live with melasma; over 90% coming from all cases are women. Prevention is primarily directed at facial protection from the sun and sun avoidance.
Treatments to hasten the fading of the discolored patches include: Azelaic acid (20%) Skinoren, thought to reduce the activity of melanocytes. Skinoren normalizes the disturbed keratinization processes inside follicles of skin oil glands and cuts down on the content of free essential fatty acids inside the lipids with the skin and reduces its fat content. Skinoren exhibits antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. Anti-inflammatory effect is additionally as a result of reduction in metabolism of neutrophils and decreased output of molecular oxygen species. Skinoren features a dose-dependent and time the overwhelming impact around the growth and viability of abnormal melanocytes.
Before use Skinoren, skin is thoroughly washed with pure water, cream should be used twice a day, about the affected skin, gently rubbing into skin. Individual treatment: 3-4 months - for the treatment of acne, 3 months - for melasma. Clinical improvement occurs after typically 2-4 weeks. If necessary, repeat the course - the break 1-2 months. During the therapy is required to protect your skin layer from your entire spectrum of solar radiation. In case of severe skin irritation inside the first week of treatment, apply one time per day; possible short-term removal of the drug, then the resumption after the disappearance of the signs of irritation on the recommended dose.
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