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Melasma is a kind of skin disorder affecting men and also women. It is quite commonly affecting pregnant women and is also also known as the “mask of pregnancy”. Though it could affect anyone, ladies with brownish skin discoloration have reached greatest risk. Melasma can often be for this female hormones estrogen and progesterone. It is especially common in pregnant women, females who take birth control pills (oral contraceptives) and some women taking hormone replacement therapy (HRT) during menopause. It can also be prevalent in men and females of Native American descent (for the forearms) and in males and some women of German/Russian and Jewish descent (for the face). The the signs of melasma are dark, irregular well demarcated hyperpigmented macules to patches commonly found on the upper cheek, nose, lips, upper lip, and forehead. These patches often develop gradually as time passes. Melasma does not cause some other symptoms at night cosmetic discoloration. An estimated 6 million women are living within the U.S. with melasma and 45-50 million women worldwide accept melasma; over 90% of all cases are women. Prevention is primarily targeted at facial suncreen and sun avoidance.
Treatments to hasten the fading from the discolored patches include: Azelaic acid (20%) Skinoren, shown to reduce the activity of melanocytes. Skinoren normalizes the disturbed keratinization processes inside the follicles of sebaceous glands and cuts down on content of free essential fatty acids inside lipids from the skin and reduces its fat content. Skinoren exhibits antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. Anti-inflammatory effect is also as a result of decrease in metabolism of neutrophils and decreased production of toxin oxygen species. Skinoren features a dose-dependent and time the overwhelming impact for the growth and viability of abnormal melanocytes.
Before use Skinoren, the skin is thoroughly washed with pure water, cream must be used 2 times a day, about the affected skin, gently rubbing into skin. Individual course of treatment: a couple of months - for your treatments for acne, a few months - for melasma. Clinical improvement occurs after typically 2-4 weeks. If necessary, repeat the course - the break 1-2 months. During the treatment methods are important to protect skin from your entire spectrum of solar radiation. In case of severe skin irritation inside the first week of treatment, apply once each day; possible short-term removal with the drug, accompanied by the resumption after the disappearance of signs of irritation on the recommended dose.
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